Isolated human antibody, nucleic acid, vector, cell, method for producing an antibody anti KIR human, pharmaceutical composition, and method of enhancing activity of NK cell in a patient in need of the same
Innate Pharma S.A.S;University of Genoa;Novo Nordisk A/S
发明人:
Svendsen, Ivan,Romagne, Francois,Padkjær, Søren Berg,Moretta, Alessandro,Chiesa, Mariella Della,Andre, Pascale,Gauthier, Laurent,Wagtmann, Peter Andreas Nicolai Reumert,Thórólfsson, Matthias,Svensson,
申请号：
NO20070585
公开号：
NO341198B1
申请日:
2007.01.31
申请国别(地区):
NO
年份:
2017
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide compositions and methods for controlling immune responses of subjects, and more specifically, to provide a human antibody and human monoclonal antibody which control natural killer cell activity and admit potentiation of cytotoxicity of natural killer cells in mammalian subjects.SOLUTION: The antibody includes antigen binding characteristics similar to antigen binding characteristics of 1-7F9 or 1-4F1 that is a monoclonal antibody of cross-reactivity with KIR2DL1, -2 and -3. There are also provided fragments and derivatives of the antibody； a pharmaceutical composition including the antibody, the fragments and derivatives of the antibody； and the use thereof, especially, the use thereof in treatments to increase natural killer cell activities or cytotoxicity in subjects.
