The invention discloses a composition comprising at least one long chain polyunsaturated fatty acid, at least one probiotic and a mixture of oligosaccharides, said mixture containing at least one N-acetylated oligosaccharide, at least one sialylated oligosaccharide and at least one neutral oligosaccharide, for use in the promotion of healthy bone growth and/or in the prevention and/or treatment of bone disease. Said bone disease is in particular osteomalacia, rickets, osteopenia or osteoporosis. Preferably the composition is a nutritional composition.本發明揭示包含至少一種長鏈多不飽和脂肪酸、至少一種益生菌及寡糖混合物之組合物，該混合物含有至少一種N-乙醯基化寡糖、至少一種唾液酸基化寡糖及至少一種中性寡糖，該組合物用於促進健康骨骼生長及/或預防及/或治療骨骼疾病。特別地，該骨骼疾病係骨質軟化病、佝僂病、骨量減少或骨質疏鬆症。較佳地，該組合物係營養組合物。
