The invention discloses a composition comprising at least one N-acetyl-lactosamine, at least one sialylated oligosaccharide and at least one fucosylated oligosaccharide, for use in the prevention and/or treatment of skin conditions and skin diseases. Preferably said composition is a starter infant formula. Said skin disease is in particular atopic dermatitis.本發明揭示一種組合物,其包含至少一種N-乙醯基-乳糖胺、至少一種唾液酸基化寡醣及至少一種岩藻醣基化寡醣,該組合物用於預防及/或治療皮膚病況及皮膚疾病。較佳地,該組合物係初生嬰兒配方(starter infant formula)。該皮膚疾病具體而言係異位性皮膚炎。