#$%^&*AU2010202494B220130822.pdf#####CaMftnbr3DCCISXD 3Ou6863 DOC.lOmmAOl ABSTRACT This invention relates to novel a-galactosidases for the enzymatic removal of the immunodominant monosaccharides on blood products and tissues. Specifically this 5 invention provides a novel family of a3 glycosidases, used for the enzymatic removal of type B antigens from blood group B and AB reactive blood products, and the Galili antigen from non-human animal tissues, thereby converting these to non-immunogenic cells and tissues suitable for transplantation.