#$%^&*AU2010202013B220130815.pdf#####C NRPorb DCC SXD2964901_I.DOC.lDS/20IO ABSTRACT This invention relates to novel a-galactosidases for the enzymatic removal of the immunodominant monosaccharides on blood products and tissues. Specifically this 5 invention provides a novel family of a3 glycosidases, used for the enzymatic removal of type B antigens from blood group B and AB reactive blood products, and the Galili antigen from non-human animal tissues, thereby converting these to non-immunogenic cells and tissues suitable for transplantation.