#$%^&*AU2013203945A120130509.pdf#####H:\fmntntenvoven\NRPortb\DCC\FM\565483_I,DOC-10/04/2013 ABSTRACT This invention relates to novel a-galactosidases for the enzymatic removal of the immunodominant monosaccharides on blood products and tissues. Specifically this invention provides a novel family of a3 glycosidases, used for the enzymatic removal of type B antigens from blood group B and AB reactive blood products, and the Galili antigen from non-human animal tissues, thereby converting these to non-immunogenic cells and tissues suitable for transplantation.