您的位置: 首页 > 农业专利 > 详情页

Parenteral peptide formulations for the treatment of systemic lupus erythematosus
专利权人:
Yeda Research and Development Co.
发明人:
COHEN-VERED, Sharon,NAFTALI, Esmira,WEINSTEIN, Vera,GILBERT, Adrian,KLINGER, Ety
申请号:
ES04702215
公开号:
ES2606464T3
申请日:
2004.01.14
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A pharmaceutical composition comprising; an aqueous carrier; 0.1 mg / ml to 20 mg / ml of the composition of a pharmaceutically acceptable salt of a peptide comprising consecutive amino acids having the sequence (i) TGYYX1X2X3X4XSQSPEKSLEWIG (SEQ ID NO: 11) where X1 is Met, Ala or Val; X2 is Gln, Asp, Glu or Arg; X3 is Trp or Ala; X4 is Val or Ser; and X5 is Lys, Glu or Ala; (ii) EINPSTGGX6X7X8X9X10X11X12KAKAT (SEQ ID NO: 12) where X6 and X7 are each Thr, Val or Ala; X8 is Tyr or Phe; X9 is Asn or Asp; X10 is Gln or Glu; X11 is Lys or Glu, and X12 is Phe or Tyr; (iii) YYCARX13X14X15X16PYAX17X18YWGQGS (SEQ ID NO: 13) where X13 is Phe, Thr or Gly; X14 is Leu, Ala or Ser; X15 is Trp or Ala; X16 is Glu or Lys; X17 is Met or Ala, and X18 is Asp, Lys, or Ser; (iv) GYNX19X20X21X22X23X24SHGX25X26LEWIG (SEQ ID NO: 14) where X19 is Met or Ala; X20 is Asn, Asp or Arg; X21 is Trp or Ala; X22 is Val or Ser; X23 is Lys or Glu; X24 is Gln or Ala; X25 is Lys or Glu, and X26 is Ser or Ala; (v) YYCARX27X28X29YGX30X31X32GQTL (SEQ ID NO: 15) where X27 is Ser or Phe; X28 is Gly or Ala; X29 is Arg, Ala or Glu; X30 is Asn or Asp; X31 is Tyr or Phe, and X32 is Trp, His or Ala; (vi) X33YYWSWIX34QX35PX36X37GX38EWIG (SEQ ID NO: 16) where X33 is Gly or Thr Gly; X34 is Arg or Lys; X35 is Pro or Ser; X36 is Gly or Glu; X37 is Lys or Asp; and X38 is Glu, Leu, or Ser; (viii) FSGYYWS (SEQ ID NO: 8); (ix) EINHSGSTNYKTSLKS (SEQ ID NO: 9); or (x) GLLRGGWNDVDYYYGMDV (SEQ ID NO: 10), and a substituted β-cyclodextrin as a selected solubility enhancer y, where both the peptide and the solubility enhancer are dissolved in the aqueous carrier; and where the composition has a pH between 4 and 9.Una composición farmacéutica que comprende; un portador acuoso; de 0.1 mg/ml a 20 mg/ml de la composición de una sal farmacéuticamente aceptable de un péptido que comprende aminoácidos consecutivos que tienen la secuencia (i) TGYYX1X2X3X4XSQSPEKSLEWIG (SEQ ID NO:11) donde X1 es Met, Ala o Val; X2 es Gln, Asp, Glu o Ar
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充