Mark Youngman;Chiyou Ni;Bin Shao;Minnie Park;Jiangcho Yao;Laykea Tafesse
发明人:
Chiyou Ni,Bin Shao,Laykea Tafesse,Jiangcho Yao,Mark Youngman,Minnie Park
申请号：
US14342054
公开号：
US09163008B2
申请日:
2012.08.31
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A1, X, A2, W1, W2, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
