LIMITED;DAIICHI SANKYO COMPANY;DAIICHI SANKYO COMPANY, LIMITED;PEPTIDREAM INC.
发明人:
YAMAGUCHI, TAKAHIRO,MORI, YUTAKA,SAITO, HIRONAO,KUBOTA, HIDEKI,FURUKAWA, AKIHIRO,OTSUKA, ERI,ISHIGAI, YUTAKA,IJIRI, HIROSHI,REID, PATRICK
申请号：
CA3036424
公开号：
CA3036424A1
申请日:
2017.09.13
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Provided is a compound which can promote angiogenesis by inhibiting the function of TSP1, and is useful in the treatment or prevention of diseases such as critical limb ischemia. Specifically provided is a macrocyclic polypeptide represented by formula (1) [in the formula: A is selected from among linking groups A1 to A6； Xaa1 is an aliphatic amino acid, aromatic amino acid, basic amino acid, neutral amino acid, or acidic amino acid residue, or is not present； Xaa2 is an aromatic amino acid or neutral amino acid residue； Xaa3 is an aliphatic amino acid, aromatic amino acid, or basic amino acid residue； Xaa4 is Ser, Thr, Ala, or mS； Xaa5 is Gly or Ser； Xaa6 is a basic amino acid or neutral amino acid residue； Xaa7 is a neutral amino acid or acidic amino acid residue； Xaa8 is an aromatic amino acid residue； Xaa9 is an aliphatic amino acid, neutral amino acid, or aromatic amino acid residue； Xaa10 is a basic amino acid, aliphatic amino acid, aromatic amino acid, or neutral amino acid residue； Xaa11 is an aromatic amino acid residue； and Xaa12 is an aliphatic amino acid, aromatic amino acid, or basic amino acid residue], or a pharmacologically acceptable salt thereof.
