PROBLEM TO BE SOLVED: To provide a composition for inhibiting transition to inflammation (redness, heat sensation, expansion, pain) by controlling activation of an epidermal cell caused by damage-associated molecular patterns (DAMPs) IL-8 gene expression, NO production or the like.SOLUTION: Perilla extract and Scutellaria root extract suppress IL-8 gene expression and NO production of an epidermal cell which is activated by DAMPs stimulation. An inflammation transition-inhibiting external composition for skin contains one type or more of an IL-8 gene expression inhibitor or an NO production inhibitor using the extract as an active ingredient.SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】ダメージ関連分子パターン(DAMPs)に起因するIL-8遺伝子発現、NO産生等による表皮細胞の活性化を制御することにより、炎症(発赤、熱感、膨張、疼痛)への移行を抑制する組成物の提供。【解決手段】DAMPs刺激により活性化された表皮細胞のIL-8遺伝子発現、NO産生を抑制する、シソ抽出物、オウゴン抽出物。前記抽出物を有効成分とするIL-8遺伝子発現抑制剤又はNO産生抑制剤の一種以上を含む炎症移行抑制皮膚外用組成物。【選択図】なし
