Ulrich Iserloh;Guoqing Li;Xiaoxiang Liu;Jared N. Cumming;Zhaoning Zhu;Andrew W. Stamford;Mihirbaran Mandal;Yusheng Wu
发明人:
Andrew W. Stamford,Zhaoning Zhu,Mihirbaran Mandal,Yusheng Wu,Jared N. Cumming,Xiaoxiang Liu,Guoqing Li,Ulrich Iserloh
申请号:
US12988461
公开号:
US08541427B2
申请日:
2009.04.21
申请国别(地区):
US
年份:
2013
代理人:
摘要:
In its many embodiments, the present invention provides certain 2-imino-3-methyl pyrrolo pyrimidone compounds, including compounds Formula (II): and include tautomers, steroisomers, or pharmaceutically acceptable salts or solvates of said compounds, stereoisomers, or said tautomers, wherein R2, R3, R4, R5, R6, R7, R8, and R9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's Disease, are also disclosed.