Zhaoning Zhu,Andrew Stamford,Mihirbaran Mandal,Xiaoxiang Liu
申请号：
US12988464
公开号：
US08450331B2
申请日:
2009.04.21
申请国别(地区):
US
年份:
2013
代理人:
摘要：
In its many embodiments, the present invention provides certain thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidone compounds, including compounds (or tautomers or a pharmaceutically acceptable salts thereof) having the structural Formula (III): wherein R2, R3, R4, R5, R6, R7, R8, and R9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's Disease, are also disclosed.
