Ken Chikauchi;Yukiko Hiraiwa;Mizuyo Ida;Akihiro Morinaka;Toshiaki Kudo;Takao Abe
发明人:
Ken Chikauchi,Mizuyo Ida,Takao Abe,Yukiko Hiraiwa,Akihiro Morinaka,Toshiaki Kudo
申请号：
US13306372
公开号：
US20120071457A1
申请日:
2011.11.29
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.
