EXPANSION DE LYMPHOCYTES INFILTRANT LES TUMEURS (TIL) AVEC DES AGONISTES DE LA SUPERFAMILLE DES RECEPTEURS DU FACTEUR DE NECROSE TUMORALE (TNFRSF) ET DES COMBINAISONS THERAPEUTIQUES DE TIL ET D'AGONISTES DE TNFRSF

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专利权人:

IOVANCE BIOTHERAPEUTICS; INC.

发明人:

LOTZE, MICHAEL T.,RITTHIPICHAI, KRIT

申请号：

CA3049163

公开号：

CA3049163A1

申请日:

2018.01.05

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

Methods of expanding tumor infiltrating lymphocytes (TILs) using a tumor necrosis factor receptor superfamily (TNFRSF) agonist, such as a 4- IBB agonist, a CD27 agonist, a glucocorticoid-induced TNF receptor-related agonist, an OX40 agonist, a HVEM agonist, or a CD95 agonist, and uses of such expanded TILs in the treatment of diseases such as cancer are disclosed herein. In addition, in some embodiments, therapeutic combinations of TILs and TNFRSF agonists useful in the treatment of diseases such as cancer, including compositions, uses, and dosing regimens thereof, are disclosed herein.

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