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PAKEISTIEJI AZOLAI, ANTIVIRUSINIS AKTYVUS INGREDIENTAS, FARMACINĖ KOMPOZICIJA, JŲ GAVIMO IR PANAUDOJIMO BŪDAS
专利权人:
Alla Chem, LLC.;Ivachtchenko, Alexandre Vasilievich;Ivashchenko, Andrey Alexandrovich;Savchuk, Nikolay Filippovich
发明人:
Ivachtchenko, Alexandre Vasilievich,Bichko, Vadim Valilievich,Mitkin, Oleg Dmitrievich
申请号:
LT14002393
公开号:
LT2808325T
申请日:
2011.11.28
申请国别(地区):
LT
年份:
2018
代理人:
摘要:
The present invention relates to novel azoles, novel antiviral active components of the general formulas 1A and 1B , pharmaceutical composition, antiviral medicament, method for prophylaxis and treatment of viral diseases, particularly caused by hepatisis C viruses (HCV). In general formulas 1A and 1B wherein: solid lines with accompanying dotted lines ( --- ) represent ordinary bond or double bond, provided that one of them is an ordinary bond, the other one is double bond; X and Y accept various meanings, one of them is - nitrogen, the other - oxygen, sulfur or NH group; R 1 and R 2 - optionally the same radicals selected from 2-(R)- and (S)- substituted N-acyl pyrrolidine derivatives; N-methyl-N-[2-(R) and (S)- substituted 2,2-disubstituted acetamides; methyl[2-(R) and (S)-substituted ((methyl)amino)-(1-oxobutan-2-yl)-2-(R)-] and (S)-iso-propyl)-carbamates. A represents aliphatic C 2 -C 8 biradical; dioxane, cyclo- and bicycloaliphatic, alkyloxyalkyl, alkyloxyalkylenoxyalkyl, alkenyloxyalkyl, alkynyloxyalkyl biradicals and their thioanaloges; aryl and thiophene alkynylcycloalkyl, alkynyldioxane, alkynylaryl, alkylthiophene, alkenylthiophene and alkynylthiophene, alkyloxyaryl, alkenyloxyaryl, alkynyloxyaryl, alkylthioaryl, alkenylthioaryl, alkynylthioaryl, cycloalkylthiophene, aryldioxane and thiophenyldioxane biradicals. B represents: aliphatic C 2 -C 8 radical, including 1,2 or 3 triple C‰¡C bonds; aryl and thiophene, alkynylcycloalkyl, alkynyldioxane, alkynylaryl, alkylthiophene, alkenylthiophene and alkynylthiophene, cycloalkylbenzene, 4-cycloalkylbiphenyl, bicycloalkylbenzene, 4-bicycloalkylbiphenyl, cycloalkylthiophene, aryldioxane and thiophenyldioxane radicals.
来源网站:
中国工程科技知识中心
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