The invention relates to thiophene derivatives of formula (I)/their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents wherein: A represents *—CO—CH═CH—, *—CO—CH2CH2—, *—CO—CH2—NH—, wherein the asterisks indicate the bond that is linked to the thiophene group of Formula (I), and R1-R3 are as defined in the claims.본 발명은 신규한 티오펜 유도체, 이들의 제조 및 제약학적 활성 화합물로서 이들의 용도에 관계한다. 상기 화합물은 특히, 면역억제제(immunosuppressive agent)로서 기능한다.