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3,5-diamino-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of the airways.
专利权人:
NOVARTIS AG
发明人:
CATHERINE HOWSHAM,STEPHEN PAUL COLLINGWOOD,THOMAS ANTHONY HUNT
申请号:
BRPI0912542
公开号:
BRPI0912542A2
申请日:
2009.05.11
申请国别(地区):
BR
年份:
2015
代理人:
摘要:
A compound of Formula I in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8 and R9 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
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