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3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases
专利权人:
Thomas Anthony Hunt;Stephen Paul Collingwood;Catherine Howsham
发明人:
Stephen Paul Collingwood,Catherine Howsham,Thomas Anthony Hunt
申请号:
US12990905
公开号:
US08664228B2
申请日:
2009.05.11
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A compound of Formula Iin free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8 and R9 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
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