McCauley,Dilara,Sandanayaka, Vincent P.,Shacham, Sharon,Shechter, Sharon
申请号：
AU2016210682
公开号：
AU2016210682B2
申请日:
2016.08.04
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2016210682B220180419.pdf#####ABSTRACT OF THE INVENTION The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I: N-N NH / '>； O N-R 2 F3C N R R3 CF 3 (1) or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity. (11J610033N
