The Chemo-Sero-Therapeutic Research Institute;National University Corporation Kumamoto University
发明人:
申请号：
EP15743230.3
公开号：
EP3101131A1
申请日:
2015.01.23
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
A humanized antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The humanized antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a humanized antibody suitable for application to human body.
