SCHNEIDER, Artur,SCHELLER, Jürgen,LANG, Philipp,FLOSS, Doreen,ENGELOWSKI, Erika,XU, Haifeng,FRANKE, Manuel
申请号：
EPEP2019/058741
公开号：
WO2019/193197A1
申请日:
2019.04.08
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
In a first aspect, the present invention relates to new recombinant artificial polypeptides allowing cytoplasmic signaling in cells containing the same. In particular, the present invention relates to a system for transmitting signals containing a recombinant polypeptide containing a domain with a first binding partner selected from an artificial ligand and a receptor binding an artificial ligand, a transmembrane domain and a cytoplasmic signaling domain whereby the domain with the binding partner and the cytoplasmic signaling domain are a combination of domains not naturally occurring in an organism and the second binding partner for specific forming of the binding pair. In a further aspect, a nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide according to the present invention as well as a vector, cell, cell line or host cell containing said vector are provided. In addition, the present invention relates to the use of the recombinant polypeptide according to the present invention in treating cancer or autoimmune disease or allowing immune modulation of a subject as well as for use to change the status of cells when applying the specific second binding partner of the first binding partner present in the recombinant polypeptide according to the present invention.Dans un premier aspect, la présente invention concerne de nouveaux polypeptides artificiels recombinants permettant une signalisation cytoplasmique dans des cellules contenant ceux-ci. En particulier, la présente invention concerne un système de transmission de signaux contenant un polypeptide recombinant contenant un domaine avec un premier partenaire de liaison choisi parmi un ligand artificiel et un récepteur se liant à un ligand artificiel, un domaine transmembranaire et un domaine de signalisation cytoplasmique, le domaine avec le partenaire de liaison et le domaine de signalisation cytoplasmique étant une combinaison de domaines non présents naturellement dans un organism
