The present invention relates to promotion of longevity. The present invention relates to an active substance of lactic acid bacteria for promoting longevity, particularly for increasing Cisd2 gene expression, reducing mitochondrial damage and delaying aging conditions such as neurodegeneration and sarcopenia, and a composition containing the same. And its use. [Selection diagram] Figure 1【課題】本発明は、長寿促進に関する。【解決手段】本発明は、長寿促進のための、特にＣｉｓｄ２遺伝子発現の増加、ミトコンドリア損傷の減少ならびに神経変性およびサルコペニア等の老化状態の遅延のための、乳酸菌の活性物質、それを含む組成物及びその利用を提供する。【選択図】図１
