An infusion control device controls the infusion of a liquid in an extracorporeal blood circuit having an arterial pipe (12) and a venous pipe (15) respectively connected to an inlet and an outlet of a blood compartment (5) of a filter (4) the infusion control device comprises a control unit (31) that determines a sequence of infusion in the extracorporeal blood circuit, from a characteristic value (FF, TMPave, Kuf) correlated with the concentration of the blood (CE) and/or a filtration efficiency of the filter (4), and that controls the infusion in the arterial pipe (12) and in the venous pipe (15) in accordance with the determined infusion sequence.