LOCKMAN, Jeffrey,NI, Chiyou,PARK, Jae Hyun,PARK, Minnie,SHAO, Bin,TAFESSE, Laykea,YAO, Jiangchao,YOUNGMAN, Mark
申请号：
ES14710633
公开号：
ES2680246T3
申请日:
2014.03.03
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound having Formula V: ** Formula ** or a pharmaceutically acceptable salt or solvate thereof, A1 is selected from the group consisting of: ** Formula ** R28a is selected from the group consisting of hydrogen, fluoro , chloro, cyano, C1-4 halogenoalkyl, C1-4 halogenoalkoxy, (C1-C4 halogenoalkoxy) alkyl, C1-4 alkoxy, C1-C4 alkyl and C1-C6 cycloalkyl； R28b is selected from the group consisting of hydrogen, fluoro, chloro, cyano, C1-4 halogenoalkyl, C1-4 halogenoalkoxy, (C1-C4 halogenoalkoxy) alkyl, C1-4 alkoxy, C1-C4 alkyl and C1-C6 cycloalkyl； or R28a and R28b taken together with the two adjacent carbon atoms form a 5- or 6-membered cycloalkyl or heterocycle； R28c is selected from the group consisting of hydrogen, heteroaryl and (heterocycle) alkyl, or Z is selected from the group consisting of -NR5- and -O-； R4 is selected from the group consisting of: ** Formula ** R1a is selected from the group consisting of hydrogen and (heterocycle) alkyl； R10a is selected from the group consisting of alkyl and hydroxyalkyl； R12 is selected from the group consisting of hydrogen, alkyl, alkenyl and hydroxyalkyl； R5 is hydrogen； or R4 and R5 taken together with the nitrogen atom to which they are attached form an optionally substituted heterocycle selected from the group consisting of: ** Formula ** R14 is selected from the group consisting of hydrogen and C1-C4 alkyl.Un compuesto que tiene la Fórmula V:**Fórmula** o una sal o solvato farmacéuticamente aceptable del mismo, A1 se selecciona de entre el grupo consistente en:**Fórmula** R28a se selecciona de entre el grupo consistente en hidrógeno, fluoro, cloro, ciano, halogenoalquilo C1-4, halogenoalcoxi C1-4, (halogenoalcoxi C1-C4)alquilo, alcoxi C1-4, alquilo C1-C4 y cicloalquilo C1-C6； R28b se selecciona de entre el grupo consistente en hidrógeno, fluoro, cloro, ciano, halogenoalquilo C1-4, halogenoalcoxi C1-4, (halogenoalcoxi C1-C4)alquilo, alcoxi C1-4, alquilo C1-C4 y cicloalquilo C1-C6； o R28a y R28b tomados junto con l
