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BENZIMIDAZOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS
专利权人:
ACTELION PHARMACEUTICALS LTD
发明人:
HUBLER FRANCIS,HILPERT KURT,RENNEBERG DORTE
申请号:
ZA201008448
公开号:
ZA201008448B
申请日:
2010.11.24
申请国别(地区):
ZA
年份:
2012
代理人:
摘要:
The invention relates to compounds of formula (I) wherein R1 represents aryl, which is unsubstituted, or mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, and trifluoromethyl; R2 represents hydrogen, or —CO—R21; R21 represents (C1-5)alkyl, (C1-3)fluoroalkyl, or (C3-6)cycloalkyl; m represents the integer 2, or 3; p represents the integer 2 or 3; and R3 represents hydrogen, or (C1-5)alkyl; and pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.
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