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Pyrrolopyrazolas as N-type calcium channel blockers
专利权人:
Janssen Pharmaceutica NV
发明人:
WINTERS, Michael P.,SUI, Zhihua
申请号:
ES13762619
公开号:
ES2607839T3
申请日:
2013.08.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of Formula (I) ** Formula ** wherein R1 is selected from the group consisting of C1-4alkyl, C1-4alkoxy, 2,2-difluoroethoxy, di (C1-4alkyl) amino, trifluoromethoxy, fluorine, and trifluoromethyl; R2 is hydrogen; or, R2 can be taken with R1 and the phenyl ring to which R1 and R2 are attached to form 2,3-dihydrobenzofuran-7-yl or 1,3-benzodioxol-4-yl; R3 is hydrogen, methyl, methoxy, chlorine, or fluoro; Q is selected from the group consisting of Q1, Q2, and Q3; ** Formula ** where R4 is selected from the group consisting of hydrogen, C1-4alkyl, C1-4alkoxy, cyano, fluoro, and chlorine; R5 is independently selected from the group consisting of hydrogen, C1-4alkyl, C1-4alkoxy, cyano, chlorine, and di (C1-4alkyl) amino; G is selected from the group consisting of 4-methylphenyl, 3-cyanophenyl, 4-cyanophenyl, 4-methoxycarbonylphenyl, 2- chloro-quinoline-6-yl, morpholine-4-yl-sulfonyl, morpholine-4-yl (C1- 4alkyl) aminosulfonyl, 2,6-dimethyl-morpholine-4-yl-sulfonyl, C6-10aryl (C1-4) alkylsulfonyl, C6-10aryloxy (C1-4) sulfonyl, 3,5-dimethylisoxazol-4-yl-sulfonyl, C1-4alkoxy (C1-4) alkyl-sulfonyl, trifluoromethylsulfonyl, C3-7cycloalkylsulfonyl, 2,2,2-trifluoroethylsulfonyl, di (C1-4alkyl) aminosulfonyl, di (C1-4alkyl) aminosulfonylamino (C1-4) alkyl-sulfonyl, C1-4alkylsulfonylamino (C1-4) alkyl-sulfonyl, 2,5-dione-pyrrolidine-1-yl- (C1-4) alkyl-sulfonyl, (2H) -1,3-dione-1H-iso-indole-1 -yl- (C1-4) alkyl-sulfonyl, 1,1-diox- (idotetrahydrothiophene-3-yl) sulfonyl, C1-6alkylsulfonyl, di (C1-4alkyl) aminosulfonyl, pyrrolidine-1-yl-sulfonyl, piperidine-1 -yl-sulfonyl, 4- (R6) -piperidine-1-yl-sulfonyl in which R6 is C1-4alkoxycarbonyl or C1-4alkyl; azepan-1-yl-sulfonyl, methoxymethylcarbonyl, trifluoromethylcarbonyl, C 1-4 alkoxy (C2- 4) alkyl-carbonyl, C1-4alcoxicarbonilaminometilo-carbonyl, trifluorometilsulfonilaminometililcarbonilo, trifluoromethoxycarbonyl, C1-4alquilsulfonilaminometilo-carbonyl, C1-4alcoxicarbonilo, di (C1- 4alquil) aminocarbonyl, C1-4alkoxycarbo
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