Oliver Hill,Christian Gieffers,Meinolf Thiemann,Fritz G. Buchanan,Darren C. Phillips,Susan E. Lappe
申请号：
US14694358
公开号：
US09908927B2
申请日:
2015.04.23
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are specific TRAIL receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a TRAIL-associated disease or disorder. The TRAIL receptor agonist proteins provided herein comprise three soluble TRAIL domains and an Fc fragment. The TRAIL receptor agonist proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
