JAY BRADFORD FELL,JOHN P. FISCHER,RONALD J. HINKLIN
申请号：
ARP120104310
公开号：
AR089177A1
申请日:
2012.11.15
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
They are gpr119 modulators that help to treat or prevent diseases such as, but not limited to, type II diabetes, diabetes symptoms, metabolic syndrome, obesity, degreasing and related diseases. Claim 1: a compound whose formula (1) or salts are acceptable in the substance, wherein X1 is n or CR1, X2 is n or CR2,provided that only one of X¹ and X² is N； Rˣ is H or C₁₋₃ alkyl；R1,R2,The selection of R3 and r830808 is independent of H, halogen and cf.83323；1. Lease land No. c833218331 and 832626；Cn and alcoxi c83218sp31832626；R es alquil C sulfonilo cicloalquil C sulfonilo (ciclopropilmetil) sulfonilo fenilsulfonilo CN RRNHC (3DO) -alcoxi C C O q CR and R are independently H or C₁₋₄ alkyl optionally substituted with OH, or R and R together with atom to which they are attached form a 5- to 6-membered heterocyclic ring having a ring nitrogen atom and optionally having a second heteroatom of the ring selected from N and O, wherein said ring is optionally substituted with OH or NH₂；R831111 was selected from the formula group (2)；R7491,R74955,Rᶜ and Rᵈ are independently H or halogen； R⁸ is selected from halogen, C₁₋₆ alkyl,C₁₋₆ fluoroalkyl,2. Difluoroalkyl compound c83218c83316262；R8313 is hydrogen or c8332131 / 832323；R1 830404 is hydrogen or c83218331s 832323；N is 1,2,3. When n is 2,3, only one r183044 can be methyl.Son moduladores de GPR119 y son útiles en el tratamiento o prevención de enfermedades tales como, pero de modo no taxativo, diabetes tipo 2, complicaciones diabéticas, síntomas de diabetes, síndrome metabólico, obesidad, dislipidemia y afecciones relacionadas. Reivindicación 1: Un compuesto que tiene la fórmula (1) o una sal farmacéuticamente aceptable de este, donde: X¹ es N o CR¹ y X² es N o CR², siempre que solo uno de X¹ y X² sea N； Rˣ es H o alquilo C₁₋₃； R¹, R², R³ y R⁴ se seleccionan independientemente de H, halógeno, CF₃, alquilo C₁₋₆, CN y alcoxi C₁₋₆； R⁵ es alquil C₁₋₃sulfonilo, cicloalquil C₃₋₆sulfonilo, (ciclopropilmetil)sulfonilo, fenilsulfonilo,
