KETELSON, HOWARD ALLEN,凯特森 霍华德A,凱特森 霍華德A,DAVIS, JAMES W.,戴维斯 詹姆斯W,戴維斯 詹姆斯W,MEADOWS, DAVID L.,米道斯 大卫L,米道斯 大衛L
申请号：
TW098113635
公开号：
TWI526213B
申请日:
2009.04.24
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention relates to artificial tear formulations and ophthalmic formulations suitable for drug delivery. The formulations comprise galactomannans such as guar or hydroxypropyl guar and a borate source such as boric acid. The formulations further comprise a cis-diol such as sorbitol that interferes with the cross-linking of galactomannan and borate. Optionally, the formulations are substantially free of divalent cations.本發明係關於人工淚液配方及適合用於藥物遞送之眼科配方。該配方包含半乳甘露聚糖,例如瓜爾豆膠或羥丙基瓜爾豆膠及硼酸鹽來源,例如硼酸。該配方進一步包含順式二醇,例如山梨醇,其可干擾半乳甘露聚糖及硼酸鹽之交聯作用。選擇性地,該配方係實質上無二價陽離子。
