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Octahidro derived from pyrrolo [3,4-c] - phenyl pyrrole and Pyridine
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
PATRIZIO MATTEI,HARALD MAUSER,GUOZHI TANG,LISHA WANG,JRME HERT,DANIEL HUNZIKER
申请号:
ARP140100780
公开号:
AR095079A1
申请日:
2014.03.10
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
Claim 1: the compound in formula (1): R1 is a cycloformyl substitute, cycloformylaki substitute, phenyl substitute, phenyl substitute, phenyl cycloformyl substitute, phenyl cycloformyl substitute, phenyl methyl substitute, phenyl acyl substitute, phenyl substitute, phenyl substitute, phenylethyl substitute, perfluorooctane sulfonic acid substitute, Substituted nafilchio, substituted nafilchiono, substituted pyridinol, substituted pyridine-chiononilo, substituted pyridine-chiononilo, substituted sulfofluoroalkyl, substituted thiophosphoryl toluene ester, substituted thiofeniakiononi, substituted Indian Lillo, substituted quinine, International Organization for Standardization2 3-dihidro-1H-isoindol-2-ilo sustituido 1H-indol-2-ilo sustituido o benzofuran-2-ilo sustituido dichos cicloalquilo sustituido cicloalquil-alquilo sustituido fenilo sustituido fenilalquilo sustituido fenoxialquilo sustituido fenilcicloalquilo sustituido fenilalquenilo sustituido fenilalquinilo sustituido naftilo sustituido naftilalquilo 1. Isoquinol, 2,3-dihydro-1h-isoindol-2-ilo, 1h-indol-2-ilo and benzofuran-2-ilo were replaced by r8311a;R8322 and r8313;R2. It is a phenyl substitute, pyridine substitute, pyridine substitute, pyridine substitute, oxodihydropirideni substitute, thifennilo substitute, pyridine substitute, pyridine substitute and thifennilo substitute;R1 and R1;This is - oc-8309; C (o),-C (O) --S (O) -a. Other formula (2) or other formula (3);A is - n-o-ch;it is life.- yes.- No. 8310th --C (O) --S (O) -or -CR³R⁴-;R³ and R⁴ are independently selected from H, halogen, alkyl and cycloalkyl; R⁵ and R⁶ are independently selected from H, alkyl and cycloalkyl; R⁷,R831222 and r8313 are independent from h, hydrocarbon, hydroxyoxy, hydroxypropyl, cyclopropyl, cyclopropyl clalquilo, cyclopropyl, cyclopropyl, cyclopropyl, cyclopropyl propyl, cyclopropyl oxy, propoxy, propyl, halogen-o-yl, halogen, alcoxiaalcox, ALCOXY ALCOXY, phenyl, phenyl, pyridyl, Nile, Substitution of pyridine, halogen, h
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