BUTTERWORTH, SAM,FINLAY, MAURICE RAYMOND VERSCHOYLE,WARD, RICHARD ANDREW,KADAMBAR, VASANTHA KRISHNA,CHANDRASEKHARA, REDDY CHINTAKUNTLA,MURUGAN, ANDIAPPAN,REDFEARN, HEATHER MARIE,CHUAQUI, CLAUDIO EDMUN
申请号：
PE2013002532
公开号：
PE20141700A1
申请日:
2012.07.25
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
It refers to a compound or a pharmaceutically acceptable salt of formula I, wherein G is derived from 4,5,6,7-tetrahydropyridine [1,5-a] pyridine-3-ilo, 1h-indi-3-ilo, 1-methyl-1h-indi-3-ilo and pyrazol [1,5-a] pyridine-3-ilo, r1-h, fluorine, chlorine, methyl ether and cyanogen, r2-methyl, and methyl, and R3 (R) - 3-dimethyl-1. (3S) - 3 - (dimethylamino) pirrolidin-1-ilo, 3 - (dimethylamine) azetidin-1-ilo, etc. The most popular compounds are: n - {4-methyl-2 - [1-methyl-3, 6-dihydro-2h-piridin-4-il] - 5 - [(5-methyl-4-pirazolo [1, 5-a] piridin-3-ilpirimidin-2-il) amine]. Prop-2-enamida；N - (5-chloro-4 - (1h-indol-3-il) pirimidin-2-il] amine} - 4-methyl-2 - [1-methyl-3, 6-dihydro-2h-piridin-4-il] fenil) prop-2-enimida； among others. He also mentioned a pharmaceutical composer The compound is a common antigen (the receptor for an epidemic growth factor) that inhibits a variant form. It's very useful for cancer treatmentSE REFIERE A UN COMPUESTO DE FORMULA I O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, DONDE: G SE SELECCIONA DE 4,5,6,7-TETRAHIDROPIRAZOLO[1,5-A]PIRIDIN-3-ILO, 1H-INDOL-3-ILO, 1-METIL-1H-INDOL-3-ILO Y PIRAZOLO[1,5-A]PIRIDIN-3-ILO； R1 ES H, FLUOR, CLORO, METILO Y CIANO； R2 ES METOXI Y METILO； Y R3 ES (3R)-3-(DIMETILAMINO)PIRROLIDIN-1-ILO, (3S)-3-(DIMETIL-AMINO)PIRROLIDIN-1-ILO, 3-(DIMETILAMINO)AZETIDIN-1-ILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-{4-METOXI-2-[1-METIL-3,6-DIHIDRO-2H-PIRIDIN-4-IL]-5-[(5-METIL-4-PIRAZOLO[1,5-A]PIRIDIN-3-ILPIRIMIDIN-2-IL)AMINO]FENIL}PROP-2-ENAMIDA； N-(5-{[5-CLORO-4-(1H-INDOL-3-IL)PIRIMIDIN-2-IL]AMINO}-4-METOXI-2-[1-METIL-3,6-DIHIDRO-2H-PIRIDIN-4-IL]FENIL)PROP-2-ENAMIDA； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE LAS FORMAS MUTADAS DEL EGFR (RECEPTOR DEL FACTOR DE CRECIMIENTO EPIDERMICO). UTIL EN EL TRATAMIENTO DEL CANCER.
