SMITH, MARK,TALAMAS, FRANCISCO XAVIER,ZHANG, JING,ZHANG, ZHUMING
申请号：
PE2014000990
公开号：
PE20141599A1
申请日:
2012.12.17
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
It refers to formula compound (I),Among them: R1 is h, below halo group or arilo； R2A and r2b are independent, h, CH2SH, or lower hydroxyl compound (1h-indol-3-ilo) methyl, (1h-indol-4-ilo) methyl, etc.； R3 is h, lower tar, lower halo group, phenyl or phenylethyl； R4 is h, lower tar, or r2b and R4 are CH2； R5 is h, etc； R6 is A.There are others The most popular compounds are: (s) - 2 - [(2R, 3S, 4S, 5R) - 2-azido-5 - (2, 4-dioxo-3, 4-dihydro-2h-pirimidin-1-ilo) - 3-fluoro-4-hydroxy-tetrahydrofuran-2-ilmethy] - phenyl phosphoramide} - isopropylpropionic acid； (s) - 2 - [(2R, 3S, 4S), 5 (R) - 5 - (4-amino-2-oxo-2h-pirimidin-1-ilo) - 2-azido-3-fluoro-4-hydroxi-tetrahydro-furan-2-ilmethoxi) - (nafteren-1-iloxi) - isopropyl phosphate； and other substances. He also mentioned a composer of pharmacology These compounds are useful in the treatment of hepatitis C virus (VHC) infection.SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE: R1 ES H, HALOALQUILO INFERIOR O ARILO； R2a Y R2b SON INDEPENDIENTEMENTE, H, CH2SH, HIDROXIALQUILO INFERIOR, (1H-INDOL-3-ILO)METILO, (1H-INDOL-4-ILO)METILO, ENTRE OTROS； R3 ES H, ALQUILO INFERIOR, HALOALQUILO INFERIOR, FENILO O FENILALQUILO INFERIOR； R4 ES H, ALQUILO INFERIOR, O R2b Y R4 JUNTOS FORMAN (CH2)3； R5 ES H, ENTRE OTROS； R6 ES a), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (S)-2-{[(2R,3S,4S,5R)-2-AZIDO-5-(2,4-DIOXO-3,4-DIHIDRO-2H-PIRIMIDIN-1-ILO)-3-FLUORO-4-HIDROXI-TETRAHIDRO-FURAN-2-ILMETOXI]-FENOXI-FOSFORILAMINO}-PROPIONATO DE ISOPROPILO； (S)-2-[[(2R,3S,4S,5R)-5-(4-AMINO-2-OXO-2H-PIRIMIDIN-1-ILO)-2-AZIDO-3-FLUORO-4-HIDROXI-TETRAHIDRO-FURAN-2-ILMETOXI]-(NAFTALEN-1-ILOXI)-FOSFORILAMINO]-PROPIONATO DE ISOPROPILO； ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTO SON UTILES PARA EL TRATAMIENTO DE LA INFECCION POR EL VIRUS DE LA HEPATITIS C (VHC)
