The Royal Institution for the Advancement of Learning/ McGill University
发明人:
Trifiro Mark,Paliouras Miltiadis,Beitel Lenore K.,Alvarado Carlos
申请号：
US201815940387
公开号：
US2018288985(A1)
申请日:
2018.03.29
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
A knock-in non-human mammal comprising a recombinant androgen receptor (AR) cassette containing an exogenous human polyglutamine (polyQ) tract encoding sequence in exon 1, wherein the human polyQ tract encoding sequence is stably integrated into the genome of the animal. Also provided are recombinant cells, fertilized eggs and tissues. The resulting animal displays a wide range of phenotypes, best characterized as Metabolic Syndrome and can be used in screening and other assays.
