HUMANIZED IL-6 AND IL-6 RECEPTOR

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专利权人:

发明人:

申请号：

HK14103209.5

公开号：

HK1190408A

申请日:

2014.04.03

申请国别(地区):

HK

年份:

2014

代理人:

摘要：

Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R± locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/