Li-Hsien Wang,Anthony T. Dore, Jr.,Sean Stevens,Andrew J. Murphy
申请号：
US16502197
公开号：
US20200008407A1
申请日:
2019.07.03
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Rα locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.
