The invention generally relates to intraluminal procedures, and, more particularly, to a catheter assembly and methodology for creating a vascular access site between vessels. The invention provides a catheter assembly configured for percutaneous introduction into and extension through a blood vessel and further configured to create a vascular access site between two closely associated vessels. The catheter assembly includes at least one catheter having both intraluminal imaging capabilities and the ability to create a vascular access site on-demand within a vessel.