Antonin DE FOUGEROLLES,Jason P. SCHRUM,Justin GUILD
申请号：
US16442168
公开号：
US20190314527A1
申请日:
2019.06.14
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.
