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IN VIVO PRODUCTION OF PROTEINS
专利权人:
Inc.;ModernaTX
发明人:
Antonin DE FOUGEROLLES,Jason P. SCHRUM,Justin GUILD
申请号:
US16442168
公开号:
US20190314527A1
申请日:
2019.06.14
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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