Sposób produkcji rekombinowanego białka TAT-HOXB4H do zastosowania jako stymulant hematopoezy in vivo

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专利权人:

Taiwan Advance Bio-Pharm Inc.

发明人:

WU, KOU-JUEY,HUANG, CHI-HUNG

申请号：

PL08153854

公开号：

PL2100968T3

申请日:

2008.03.31

申请国别(地区):

PL

年份:

2014

代理人:

摘要：

The present invention relates to a new and nonobvious method of producing the C-terminal histidine tagged TAT-HOXB4 fusion protein (TAT-HOXB4H), providing unexpected benefits of increased yield and stability to allow for in vivo administration of this protein, and pharmaceutical composition comprising an effective ingredient, TAT-HOXB4H, having stimulatory activity on the production of hematopoietic cells. More specifically, recombinant TAT-HOXB4H protein enhances engraftment of bone marrow transplants, hematopoietic reconstruction, bone marrow re-population and number of circulating stem cells, particularly after chemotherapy or irradiation.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/