Lin Rong-Hwa,Lin Shih-Yao,Hsieh Yu-Chi,Huang Chiu-Chen
申请号：
NZ63060113
公开号：
NZ630601A
申请日:
2013.12.20
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Disclosed are compounds comprising a 1-(4-aminophenyl)-2-oxo-2-(piperazin-1-yl)ethyl hydrophilic self-immolative linker, which are cleavable under appropriate conditions. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker.
