LIN RONG HWA,LIN SHIH YAO,HSIEH YU CHI,HUANG CHIU CHEN,LEE SHU HUA,TSAI YU YING
申请号：
IN201747002237
公开号：
IN201747002237A
申请日:
2017.01.20
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present disclosure provides compounds with a hydrophilic self immolative linker which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety a targeting moiety capable of targeting a selected cell population and a linker which contains an acyl unit an optional spacer unit for providing distance between the drug moiety and the targeting moiety a peptide linker which can be cleaved under appropriate conditions a hydrophilic self immolative linker and an optional second self immolative spacer or cyclization self elimination linker. In some aspects of the present disclosure the targeting moiety is an anti HER2 antibody. The present disclosures further provide compositions and methods for treating cancers.
