LIN RONG-HWA,LIN SHIH-YAO,HSIEH YU-CHI,HUANG CHIU-CHEN
申请号：
IN5884/DELNP/2015
公开号：
IN2015DN05884A
申请日:
2015.07.04
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present disclosure provides compounds with a hydrophilic self immolative linker which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety a targeting moiety capable of targeting a selected cell population and a linker which contains an acyl unit an optional spacer unit for providing distance between the drug moiety and the targeting moiety a peptide linker which can be cleavable under appropriate conditions a hydrophilic self immolative linker and an optional second self immolative spacer or cyclization self elimination linker.
