ВЛАХОВ Ионтчо Радославов (US),ЛИМОН Кристофер Пол (US)
申请号：
RU2012136587/15
公开号：
RU2012136587A
申请日:
2012.08.27
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A conjugate for drug delivery, receptor binding, comprising: (a) receptor binding group (b) a polyvalent linker and (c) two or more drugs, or analogs or derivatives thereof, wherein the receptor binding group is covalently linked to a polyvalent linker, two or more drugs, or analogs or derivatives thereof, covalently linked to a polyvalent linker ipolivalentny linker comprises one or more components selected from the group consisting of spacer linkers, allowing the release of linkers and linkers with a heteroatom and sochetaniy.2. A conjugate for drug delivery, the vitamin receptor binding to the formula: wherein (L) is selected from the group consisting of (l), (l) and (l), and combinations thereof wherein (l) is a providing release of the linker, (l) is a spacer linker, and (l) represents a linker with a heteroatom (B) represents a binding receptor for the vitamin group, n is an integer greater than 1, and (D ) in each case is independently selected drug, or an analogue or derivative thereof and each of a, b and c independently represents 0, 1, 2, 3 or 4.3. A conjugate for drug delivery, the vitamin receptor binding to the formula: wherein (L) is selected from the group consisting of (l) and (l), and combinations thereof wherein (l) is a spacer linker and (l) represents a linker with a heteroatom and each of a and b independently represent 0, 1, 2, 3 or 4 and (B) is a binding receptor for the vitamin group, n is an integer greater than 1, and (D) in each case is not
