A face mask (also called full face) for respiratory therapy, in particular for non-invasive mechanical ventilation, has a low value of CO2 rebreathing. The mask includes a shaped shell to cover at least the mouth, the nose and the eyes of a patient when the mask is worn, and includes, on said shaped shell an inlet fitting for the connection to a pipe through which a ventilation apparatus supplies the mask with a mixture of air and oxygen, and an outlet fitting, separate from said inlet fitting, for the discharge of air exhaled by the patient. With this arrangement, the mask allows drastically reducing the phenomenon of carbon dioxide rebreathing, which is very harmful for the patient subjected to ventilation.