DNA encoding an anti-CD40 IgG2 antibody having amino acid mutations

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专利权人:

KYOWA HAKKO KIRIN CO.; LTD

发明人:

Aki Matsushima,Hiroshi Namisaki,Shigenori Yagi

申请号：

US14952419

公开号：

US09587031B2

申请日:

2015.11.25

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al)； has an agonist activity； and binds to human CD40.

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