ANTICORPS COMPRENANT UNE IGG2 AYANT UNE MUTATION D'ACIDE AMINÉ

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专利权人:

Kyowa Hakko Kirin Co.; Ltd.

发明人:

申请号：

EP15190139.4

公开号：

EP2993188A1

申请日:

2010.04.20

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein at least valine at position 234, glutamine at position 237 and proline at position 331 are substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al)； has an agonist activity； and binds to human CD40.

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