ANTIBODY CONTAINING IGG2 HAVING AMINO ACID MUTATION INTRODUCED THEREIN

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专利权人:

Hiroshi Namisaki;Aki Matsushima;Shigenori Yagi

发明人:

Aki Matsushima,Hiroshi Namisaki,Shigenori Yagi

申请号：

US13265075

公开号：

US20120087927A1

申请日:

2010.04.20

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al)； has an agonist activity； and binds to human CD40.

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