ЛИНЬ Суннянь (US),ЯНЬ Линь (US),КЕКЕДЖ Ахмет (US),ЧЖУ Юйпин (US),ХАНТЕР Дэвид Н. (US),ХО Пэй (US),ФЭН Даньцин (US),НАРГУНД Рави П. (US),МОЙЕС Кристофер Р. (US),ЧЖАО Чжицян (US),ПИПИК Бренда (US),ПИССА
申请号：
RU2016116513
公开号：
RU2016116513A
申请日:
2014.10.02
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
