LIN, SONGNIAN,YAN, LIN,KEKEC, AHMET,ZHU, YUPING,HUNTER, DAVID N.,HUO, PEI,FENG, DANQING,NARGUND, RAVI P.,MOYES, CHRISTOPHER R.,ZHAO, ZHIQIANG,PIPIK, BRENDA,PISSARNITSKI, DMITRI,DUFFY, JOSEPH L.,GUIDRY
申请号：
CA2924743
公开号：
CA2924743A1
申请日:
2014.10.02
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
