Lin, Songnian,Yan, Lin,Kekec, Ahmet,Zhu, Yuping,Hunter, David N.,Huo, Pei,Feng, Danqing,Nargund, Ravi P.,Moyes, Christopher R.,Zhao, Zhiqiang,Pipik, Brenda,Pissarnitski, Dmitri,Duffy, Joseph L.,Guidry
申请号：
AU2014329567
公开号：
AU2014329567B2
申请日:
2014.10.02
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
