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Aminopirimidina derivatives as modulators of LRRK2
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
BAKER-GLENN CHARLES,BURDICK DANIEL JON,CHAMBERS MARK,CHAN BRYAN K.,CHEN HUIFEN,ESTRADA ANTHONY,GUNZNER JANET,SHORE DANIEL,SWEENEY ZACHARY KEVIN,WANG SHUMEI,ZHAO GUILING
申请号:
ARP110101920
公开号:
AR081577A1
申请日:
2011.06.03
申请国别(地区):
AR
年份:
2012
代理人:
摘要:
The method of obtaining these compounds and the method of using them in the treatment of diseases related to Republic decree rc-2 are also described, such as: Parkinson's disease - claim 1: a formula compound (1): or a salt acceptable for drugs, Where: m is the number from 0 to 3, X is: - NRA -.- that is...This is life. This is life.where r is a number from 0 to 2 and Ra is hydrogen or C1-6 alkyl; R1 is: C1-6 alkyl; C2-6 alkenyl; C2-6 alkynyl; halo C1-6 alkyl; (C1-6 alkoxy) -C 1-6 alkyl; C2-6 hydroxy-alkenyl; amino C1-6 alkyl; (C 1-6 alkylsulfonyl) -C 1-6 alkyl; C3-6 cycloalkyl optionally substituted by C1-6 alkyl; (C3-6 cycloalkyl) -C1-6 alkyl, whose C3-6 cycloalkyl portion is optionally substituted by C1-6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C 1-6 alkyl tetrahydropyranyl; tetrahydropyranyl-C 1-6 alkyl, oxetanyl; or oxetane-C1-6 alkyl; or R1 and Ra together with the atoms, to which they are attached, form a ring of three to six links,which may optionally include an additional heteroatom chosen from O, N and S and which is substituted by oxo, halogen or C1-6 alkyl; R2 is: halogen; C1-6 alkoxy; cyano; C2-6 alkynyl; C2-6 alkenyl; halo C1-6 alkyl; C1-6 haloalkoxy; C3-6 cycloalkyl, whose C3-6 cycloalkyl portion is optionally substituted by C1-6 alkyl; (C3-6 cycloalkyl) -C1-6 alkyl, whose C3-6 cycloalkyl portion is optionally substituted by C1-6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C 1-6 alkyl; acetyl; oxetanyl; or oxetane-C1-6 alkyl; R3 is: -OR4; halogen; cyano; C1-6 alkyl halo-C1-6 alkyl; C3-6 cycloalkyl optionally substituted by C1-6 alkyl;(C3-6 cycloalkyl) -C1-6 alkyl, whose C3-6 cycloalkyl portion is optionally substituted by C1-6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C 1-6 alkyl; oxetanyl; or oxetane-C1-6 alkyl; R4 is: hydrogen, C1-6 alkyl; halo C1-6 alkyl; (C1-6 alkoxy) -C 1-6 alkyl; C3-6 cycloalkyl optionally substituted by C1-6 alkyl or halogen; (C3-6 cycloalkyl) -C1-6 alkyl, whose C3-6 cycloalkyl portion is optionally substituted by C1-6 al
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